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Staff Scientist / Sr. Manager – Antibody and Oligo Lead (P-2506)

10x Genomics

This is a Contract position in Gilbert, AZ posted October 22, 2021.

At 10x Genomics, accelerating our understanding of biology is more than a mission for us.

It is a commitment.

This is the century of biology, and the breakthroughs we make now have the potential to change the world.

We enable scientists to advance their research, allowing them to address scientific questions they did not even know they could ask.

Our tools have enabled fundamental discoveries across biology including cancer, immunology, and neuroscience.

Our teams are empowered and encouraged to follow their passions, pursue new ideas, and perform at their best in an inclusive and dynamic environment.

We know that behind every scientific breakthrough, there is a deep infrastructure of talented people driving the life sciences industry and making it possible for scientists and clinicians to make new strides.

We are dedicated to finding the very best person for every aspect of our work because the innovations and discoveries that we enable together will lead to better technologies, better treatments, and a better future.

Find out how you can make a 10x difference.

About The Role We are seeking a scientific leader to join the New Product Development team and build a group dedicated to technology transfer of new oligo and antibody content as well as the buildup of internal production infrastructure.

The New Product Development team acts as the interface between early stage R&D and production and this position would be deeply embedded in both organizations.

This is a cross-disciplinary position that will work closely with groups including Molecular Biology, Computational Biology, QC, Manufacturing, and Marketing to develop and validate antibody and oligo based reagents and kits for the rapid expansion of 10Xs product portfolio.

Candidates must have a broad working knowledge of molecular biology or biochemistry and be able to apply that knowledge independently and creatively toward the development of novel NGS and in situ products.

Previous experience with product devolvement as demonstrated by significant end to end contributions toward launched products is essential.

This is a lead from the bench role with more than 50% of the time spent at the bench initially.

The successful applicant will have exceptional attention to detail and the ability to meticulously execute and analyze highly complex experiments.

Individuals applying for this position must be self-starters, strategic thinkers, action driven, flexible in changing direction and methods, thrive in a fast paced environment, excel at managing multiple priorities, succeed in communicating with all levels within the organization and provide immediate contribution.

What You Will Be Doing Drive the technology transfer phase of the product pipeline as new products move from R&D into Manufacturing in preparation for commercial launch.

Guide infrastructure development projects that would enhance 10xs ability to offer fully custom antibody and oligo content.

Lead a team of scientists from RAs to Sr.

Scientists dedicated to the development of antibodies and oligos to enhance products across al 10x product portfolios.

Hire exceptional people to build a high performing team Actively contribute to the development of single cell, spatial, and in situ products from early concept phase through post-launch sustaining activities.

Conceive, develop, validate, and implement new QC methods to assess reagents and kits through a variety of analytical and functional tests.

Independently troubleshooting and resolving reagent formulation, QC, and incoming material issues.

Design and conduct experiments to determine underlying reaction mechanisms, cause and effect, failure modes, guard band studies and optimization using DOE methodologies.

To Be Successful, You Will Need PhD in molecular biology, biochemistry, genetics, microbiology, biological engineering, analytical chemistry, or related fields.

8 years relevant biotechnology industry experience in product or process development.

Experience designing and optimizing highly multiplexed panels of antibodies and/or oligos for use in NGS or in situ workflows Broad expertise in the biological applications of oligos and antibodies and the development of oligo and antibody panels Previous work with custom reagent vendors and setting up successful, long standing OEM relationships.

Significant contributions in all stages of product development (concept to post-launch) of successful customer-facing products Previous work guiding the development of new manufacturing and production infrastructure.

Experience developing and implementing novel QC methods to assess reagent performance in both functional and orthogonal assays.

Proven ability to write SOPs and train others to successfully perform the work.

Exceptionally strong collaboration and communication skills.

Nice To Have Skills & Background Hiring, managing, and mentoring of junior staff Single cell, spatial, and/or in situ assay development experience as demonstrated by the launch of successful product lines.

Experience operating liquid handling robots and other common laboratory automation tools.

Ability to program these instruments would be very beneficial.

Expertise working with human and animal tissues and cells (preservation, sectioning, staining, imaging, etc) Experience using statistical tools, such as JMP to analyze complex data sets, create DOE experiments, and data trending.

Individuals seeking employment at 10x Genomics are considered without regards to race, color, religion, national origin, age, sex, marital status, ancestry, physical or mental disability, veteran status, gender identity, or sexual orientation.

10x does not accept unsolicited applicants submitted by third-party recruiters or agencies.

Any resume or application submitted to 10x without a vendor agreement in place will be considered unsolicited and property of 10x, and 10x will not pay a placement fee.

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